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The peptide triggers gene expression changes in over 4,000 genes that persist beyond the moment of injection (Pickart & Margolina, 2018)
Accumulation of butyryl-carnitine has been associated with abnormal mitochondrial lipid -oxidation in T2D 54 , suggesting a link between TMAO and mitochondrial dysfunction consistent with the finding that TMAO binds to protein kinase R-like endoplasmic reticulum kinase and increases mitochondrial stress 55
GLP-1 drugs curb appetite, which can lead to decreases in intake of vitamin D and calcium important for bone health
However, the mechanisms related to the synergistic protective effects of this combination therapy remains unclear
